ALKBH5-IN-4

ALKBH5-IN-4 (compound 3) is a RNA m6A demethylase ALKBH5 inhibitor with an IC50 of 0.84 μM. ALKBH5-IN-4 shows inhibitory effect on leukemia cells[1].

37510-29-5

12352005

H302, H315, H319, H335

DNA/RNA Synthesis

Cell Cycle/DNA Damage

Cancer-programmed cell death

Cancer

98.82

DMSO : 50 mg/mL (ultrasonic)

O=C(O)CSC(O)C(C1=CC=CC=C1)=O

C10H10O4S

226.25

H302, H315, H319, H335

[1]Abd El-Haleem AH, et al. Furan- and Furopyrimidine-Based Derivatives: Synthesis, VEGFR-2 Inhibition, and In Vitro Cytotoxicity. ACS Med Chem Lett. 2024 Nov 25;15 (12) :2150-2157.

Room Temperature

4°C (Powder, stored under nitrogen)

http://file.medchemexpress.com/batch_PDF/HY-W173146/ALKBH5-IN-4-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported