Alloc-Val-Ala-OH
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Alloc-Val-Ala-OH (((Allyloxy) carbonyl) -L-valyl-L-alanine) is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.
330970-70-2
((Allyloxy) carbonyl) -L-valyl-L-alanine
12352211
H315, H319
Biochemical Assay Reagents
Others
Others
99.75
OC([C@H](C)NC([C@H](C(C)C)NC(OCC=C)=O)=O)=O
C12H20N2O5
272.30
H315, H319
Room Temperature
-20°C, 3 years; 4°C, 2 years (Powder)
http://file.medchemexpress.com/batch_PDF/HY-W076556/Alloc-Val-Ala-OH-SDS-MedChemExpress.pdf
Reference compound1
No Development Reported
Beschrijving
Alloc-Val-Ala-OH (((Allyloxy) carbonyl) -L-valyl-L-alanine) is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate (ADC) pyrrolobe
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