Almotriptan (hydrochloride) -d6

Almotriptan-d6 hydrochloride is the deuterium labeled Almotriptan. Almotriptan is a 5-HT1B/1D-receptor agonist used to treat migraine.

1794782-57-2

12352005

5-HT Receptor; Isotope-Labeled Compounds

GPCR/G Protein; Neuronal Signaling; Others

Neurological Disease

97.30

10 mM in DMSO

[2H]C([2H])([2H])N(C([2H])([2H])[2H])CCC(C1=C2)=CNC1=CC=C2CS(=O)(N3CCCC3)=O.Cl

C17H20D6ClN3O2S

377.96

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Bou J, et al. Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine. Eur J Pharmacol, 2000. 410 (1) : p. 33-41.|[3]Gras J, et al. Safety profile of almotriptan, a new antimigraine agent. Effects on central nervous system, renal function and respiratory dynamics. Arzneimittelforschung, 2001. 51 (9) : p. 726-32.

Blue Ice

-20°C (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-B0383AS/Almotriptan-hydrochloride-d6-SDS-MedChemExpress.pdf

Isotope-Labeled Compounds

No Development Reported