Alpha Tubulin (TUBA1A) Mouse Monoclonal Antibody [Kloon ID: LBI2C8]

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

Carrier-free (glycerol/BSA-free) TUBA1A mouse monoclonal antibody, clone LBI2C8

B-ALPHA-1; LIS3; TUBA3

Homo sapiens tubulin alpha 1a (TUBA1A), transcript variant 1, mRNA.

7846

Q71U36

Unconjugated

Gap junction, Pathogenic Escherichia coli infection

Gap junction, Pathogenic Escherichia coli infection

WB 1:400~4000, IHC 1:150

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

TUBA1A

https://www.ncbi.nlm.nih.gov/gene/?term=7846

https://www.uniprot.org/uniprot/Q71U36