ALSFTD-antilichaam

ALSFTD (C9orf72) is considered to play a role in gender determination (1) . Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG (2) . Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster (3,4) .

203228

Q96LT7

NP_060795

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

ALSFTD Antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

ALSFTD Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ALSFTD antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

ALSFTD antibody is human, mouse and rat reactive. At least two isoforms are known to exist.

ALSFTD

Cat. No. 17-208 - A-20 Cell Slide

Chromosome 9 open reading frame 72

Homo sapiens

Takada LT and Sha SJ. Neuropsychiatric features of C9orf72-associated behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease. Alzheimers Res. Ther. 2012; 4:38.

Coon EA, Whitwell JL, Parisi JE, et al. Right temporal variant frontotemporal dementia with motor neuron disease. J. Clin. Neurosci. 2012; 19:85-91.

Snowden JS, Rollinson S, Thompson JC, et al. Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. Brain 2012; 135:693-708.

Wen X, Tan W, Westergard T, et al. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death. Neuron 2014; 84:1213-25.

Amyotrophic lateral sclerosis with frontotemporal dementia, chromosome 9 open reading frame 72, C9orf72

ELISA, WB, ICC

37039612

Liquid