ALT-2074

ALT-2074 (BXT-51071) is an orally active catalytic analogue of glutathione peroxidase. ALT-2074 is an inhibitor of human CYP3A, with its IC50 value ranging from 2.0 to 2.6 μM. ALT-2074 shows only a weak inhibitory effect on CYP3A in vivo, suggesting that it may not significantly affect the metabolism of CYP3A substrate drugs. ALT-2074 can be used to study inflammatory diseases characterized by reactive oxygen species, such as acute coronary syndrome[1].

173026-17-0

BXT-51072

12352005

H302-H315-H319-H335

Cytochrome P450; Glutathione Peroxidase

Apoptosis; Metabolic Enzyme/Protease

Inflammation/Immunology

CC1(C)CN[Se]C2=C1C=CC=C2

C10H13NSe

226.18

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Greenblatt DJ, et al. Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso- (2H) -selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase. Br J Clin Pharmacol. 2009 Dec;68 (6) :920-7.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W879508/

Reference compound1

No Development Reported

CYP3