Alveltamig
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Alveltamig (ZG006) is a trispecific anti-T cell engager (Tri-TE) targeting Delta-like ligand 3 (DLL3) and CD3. Alveltamig has two distinct DLL3 epitopes, and bridges tumor cells and T cells by strongly binding to DLL3 on tumor cells and CD3 on T cells, thereby mediating T cell-specific killing of DLL3-expressing tumor cells. Alveltamig can be used for the study of small cell lung cancer (SCLC) or neuroendocrine carcinoma (NEC) [1].
ZG006
12352005
CD3
Immunology/Inflammation
Cancer-programmed cell death
Cancer
[Alveltamig]
[1]Qiming Wang, et al. A phase 1 dose escalation and expansion study of ZG006, a trispecific T cell engager targeting CD3/DLL3/DLL3, as monotherapy in patients with refractory small cell lung cancer or neuroendocrine carcinoma. Journal of Clinical Oncology. Volume 43, Number 16_suppl.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991731/
Inhibitory Antibodies
No Development Reported
Beschrijving
Alveltamig (ZG006) is a trispecific anti-T cell engager (Tri-TE) targeting Delta-like ligand 3 (DLL3) and CD3. Alveltamig has two distinct DLL3 epitopes, and br
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