AM404-d4

AM404-d4 is the deuterium labeled AM404. AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC50 values in the low micromolar range[1]. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 μM). Neuroprotective Effect[2].

1185244-71-6

12352005

Cannabinoid Receptor; Isotope-Labeled Compounds

GPCR/G Protein; Neuronal Signaling; Others

Neurological Disease

OC1=C([2H])C([2H])=C(NC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)C([2H])=C1[2H]

C26H33D4NO2

399.60

[1] A Giuffrida, et al. Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology. J Pharmacol Exp Ther. 2001 Jul;298 (1) :7-14.|[2]Kent-Olov Jonsson, et al. AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch Toxicol. 2003 Apr;77 (4) :201-7.|[3]Marco Bortolato, et al. Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology. 2006 Dec;31 (12) :2652-9.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W777527/

Isotope-Labeled Compounds

No Development Reported