AMACR Antilichaam [2A10F3]

AMACR (alpha-methylacyl-CoA racemase) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. AMACR can be used as a positive marker for PIN. Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4) ; also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.

23600

Q9UHK6

Q9UHK6

Human

Purified truncated recombinant AMACR-His fusion protein expressed in E. Coli strain BL21 (DE3) .

2A10F3

Unconjugated

Primary Antibodies

Signal Transduction, Neuroscience

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

AMACR monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG2b

AMACR

Alpha-methylacyl-CoA racemase

Homo sapiens

Chen Q. Watson JT. Marengo SR. et al. Cancer Lett. 2006, Dec 8, 244 (2) :274-88.Epub 2006 Feb 23.

Epstein JI. Herawi M. J Urol. 2006, Mar, 175 (3 Pt 1) :820-34. Review.

2-methylacyl-CoA racemaseRM, RACE, CBAS4, AMACRD

ELISA, WB, IHC

313104070