AMG-424

AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 & CD3E. AMG-424 kills CD38-expressing cancer cells, triggers T-cell proliferation and attenuates cytokine release. AMG 424 has antitumor activity in a bone marrow-invasive mouse cancer model and induces peripheral B-cell depletion in cynomolgus monkeys. AMG-424 can be used in multiple myeloma research. Recommended isotype control: half-IG G1-kappa/ (scFv-heavy-lambda) -h-CH2-CH3[1].

XmAb968

12352203

CD38

Immunology/Inflammation

Cancer-programmed cell death

Cancer

[AMG-424]

[1]Zuch de Zafra CL, et al. Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release. Clin Cancer Res. 2019 Jul 1;25 (13) :3921-3933.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P991461/

Inhibitory Antibodies

No Development Reported