AMG-628
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
AMG-628 is an orally active inhibitor for TRPV1, that inhibits Capsaicin or acid (pH 5) -induced Ca2+ influx into TRPV1- expressing CHO cell with IC50 of 4.9 and 3.1 nM. AMG-628 exhibits analgesic activity in Capsaicin (HY-10448) -induced rat model, and exhibits a half-life of 2.4 h in rats[1].
862269-93-0
12352005
TRP Channel
Membrane Transporter/Ion Channel; Neuronal Signaling
Neurological Disease
CC(NC1=NC2=C(OC3=NC=NC(N4CCN([C@@H](C5=CC=C(F)C=C5)C)CC4)=C3)C=CC=C2S1)=O
C25H25FN6O2S
492.57
[1]Wang HL, et al., Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J Med Chem. 2007 Jul 26;50 (15) :3528-39.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W931056/
Reference compound1
No Development Reported
Beschrijving
AMG-628 is an orally active inhibitor for TRPV1, that inhibits Capsaicin or acid (pH 5) -induced Ca2+ influx into TRPV1- expressing CHO cell with IC50 of 4.9 an
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