AMG-9810
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
545395-94-6
C12328-5mg
TRP Channel
Neuronal Signaling
CC (C) (C) C1=CC=C (/C=C/C (=O) NC2=CC=C3OCCOC3=C2) C=C1
C21H23NO3
AMG-9810 is a potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.
3 years -20°C powder
Beschrijving
AMG-9810 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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