Amiloride-15N3

Amiloride-15N3 (MK-870-15N3) is 15N labeled Amiloride. Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]) . Amiloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.

1217169-93-1

MK-870-15N3

12352005

Apoptosis; Isotope-Labeled Compounds; Sodium Channel; TRP Channel

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Metabolism-protein/nucleotide metabolism

Metabolic Disease; Cardiovascular Disease

[15NH]=C([15NH2])[15NH]C(C1=NC(Cl)=C(N)N=C1N)=O

C6H8ClN4 15N3O

232.61

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303 (12) : p. L1013-26.|[3]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20 (1) :109-17.|[4]Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29 (7) :1176-91.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0285S/

Isotope-Labeled Compounds

No Development Reported