AML1 (RUNX1) Antilichaam

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.

861

Q01196

NP_001116079.1

Human, Mouse, Rat

AML1 (RUNX1) antibody was raised against a peptide sequence around aa.6~10 (D-A-S-T-S) derived from Human AML1 (RUNX1) .

Unconjugated

Primary Antibodies

Stem Cell

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

55 kDa

This antibody detects endogenous level of total AML1 (RUNX1) protein.

Western Blot: 1:500~1:1000

RUNX1

Runt-related transcription factor 1

Homo sapiens

Mao S., Frank R. C., Zhang J., Miyazaki Y., Nimer S. D. Mol. Cell. Biol. 19:3635-3644 (1999) Pelletier N., Champagne N., Stifani S., Yang X. -J. Oncogene 21:2729-2740 (2002) Cho J. -Y., Akbarali Y., Zerbini L. F., Gu X., Boltax J., Wang Y., Oettgen P., Zhang D. -E., Libermann T. A. J. Biol. Chem. 279:19512-19522 (2004)

AML1, CBFA2, EVI-1, AMLCR1, PEBP2aB, AML1-EVI-1

WB

169790837

Liquid