AMOTL2 Antilichaam / Angiomotine-achtig eiwit 2

AMOTL2 is a member of the angiomotin family of proteins, which are involved in the development and maintenance of blood vessels. It functions as a scaffold protein that helps to organize signaling pathways involved in cell growth and movement. Studies have shown that AMOTL2 is essential for normal development and function of multiple tissues and organs, including the heart, lungs, and kidneys. One of the most intriguing aspects of AMOTL2 is its potential role in cancer progression. Research has shown that dysregulation of AMOTL2 expression is associated with various types of cancer, including breast, lung, and prostate cancer. In some cases, AMOTL2 acts as a tumor suppressor, inhibiting cancer cell growth and metastasis. In other cases, it can promote tumor progression by enhancing angiogenesis and invasiveness.

Western blot: 1:1000-1:2000

Q9Y2J4

Human

A portion of amino acids 126-152 from the human protein was used as the immunogen for the AMOTL2 antibody.

WB

Antigen affinity

Purified

This AMOTL2 antibody is available for research use only.

Aliquot the AMOTL2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

The stated application concentrations are suggested starting points. Titration of the AMOTL2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Western blot testing of human 1) A431, 2) A375, 3) HUVEC and 4) Caco-2 cell lysate with AMOTL2 antibody. Predicted molecular weight ~86 kDa.