AMPKER1 / AMPKUP2 (Ab 174 / 172) Antilichaam

Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

5562;5563

Q13131

NP_006242.5; NP_006243.2

Human, Mouse, Rat

AMPKa1/AMPKa2 (Ab-174/172) antibody was raised against a peptide sequence around aa. 172~176/170~174 (L-R-T-S-C) derived from Human AMPKα1/AMPKα2.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

63 kDa

This antibody detects endogenous level of total AMPKα1/AMPKα2 protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

PRKAA1 PRKAA2

Protein kinase, AMP-activated, alpha 1 catalytic subunit / protein kinase, AMP-activated, alpha 2 catalytic subunit

Homo sapiens

Hurley RL, et al. (2005) J Biol Chem. Aug 12; 280 (32) : 29060-29066Woods A, et al. (2003) Curr Biol. Nov 11; 13 (22) : 2004-2008Nielsen JN, et al. (2003) J Appl Physiol. Feb; 94 (2) : 631-641Da Silva Xavier G, et al. (2000) Proc Natl Acad Sci U S A. Apr 11; 97 (8) : 4023-4028.

AMPK, AMPKa1, MAPTL, MTBT1, TAU

WB, IHC, IF

94557301 / 46877068

Liquid