Amullosporine A

Ampullosporin A is a peptaibol-type polypeptide that can be isolated from the fungus Sepedonium ampullosporum HKI-0053, exhibiting neuroleptic-like activity. Ampullosporin A can inhibit hyperactivity induced by NMDA receptor antagonist MK-801 and ameliorate social behavior abnormalities caused by subchronic drug treatment. Ampullosporin A alters the activity of glutamate receptors without affecting dopamine D1 and D2 receptors[1].

197960-94-4

12352005

IGluR

Membrane Transporter/Ion Channel; Neuronal Signaling

Neuroscience-Neurodegeneration

Neurological Disease

CC(C)C[C@@H](CO)NC([C@H](CCC(N)=O)NC(C(C)(C)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC(C(C)(C)NC(C(C)(C)NC(C(C)(C)NC([C@H](CCC(N)=O)NC(C(C)(C)NC([C@H](CC(C)C)NC(C(C)(C)NC(C(C)(C)NC([C@H](C)NC([C@@H](NC(C)=O)CC1=CNC2=CC=CC=C12)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

C77H127N19O19

1622.95

[1]Berek I, et al. Ampullosporin A, a peptaibol from Sepedonium ampullosporum HKI-0053 with neuroleptic-like activity[J]. Behavioural brain research, 2009, 203 (2) : 232-239.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N5159/

Natural Products

No Development Reported