Amyloïde beta A4 (fosfo Thr743/668) Antilichaam

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G (O) and JIP. Inhibits G (o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.

351

P05067

NP_000475.1

Human, Mouse, Rat

Amyloid beta A4 (phospho Thr743/668) antibody was raised against a peptide sequence around phosphorylation site of threonine 743 /668 (A-V-T (p) -P-E) derived from Human Amyloid beta A4.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

140 kDa

IgG

The antibody detects endogenous levels of Amyloid beta A4 only when phosphorylated at threonine 743/668.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

APP

Amyloid beta (A4) precursor protein

Homo sapiens

Ming-Sum Lee J. Cell Biol., Oct 2003; 163: 83.

Tadashi Nakaya and Toshiharu Suzuki Genes Cells, Jun 2006; 11: 633 - 645

Keun-A Chang, Mol. Cell. Biol., Jun 2006; 26: 4327 – 4338.

Thor D. Stein J. Neurosci., Sep 2004; 24: 7707 - 7717

A4, AD1, APP, APPI, Beta-amyloid protein 42

WB, IHC, IF

28721

Liquid