Amyloïde Precursor Protein (APP) Mouse Monoclonal Antibody [Kloon ID: LBI2B10]

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy) . Multiple transcript variants encoding several different isoforms have been found for this gene.

Carrier-free (BSA/glycerol-free) APP mouse monoclonal antibody, clone LBI2B10

AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2

Homo sapiens amyloid beta precursor protein (APP), transcript variant 1, mRNA.

351

P05067

Unconjugated

Alzheimer's disease

Alzheimer's disease

WB 1:2000, IHC 1:50, IF 1:50

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

APP

https://www.ncbi.nlm.nih.gov/gene/?term=351

https://www.uniprot.org/uniprot/P05067