ANA-975
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
ANA975, 5-amino-3-β -D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one derivative, is an oral prodrug of the TLR-7 agonist Isatoribine. ANA975 is converted to Isatoribine via a combined mechanism of hydrolysis by esterases and oxidation by aldehyde oxidase. ANA975 can be used in the research of hepatitis C virus infection[1].
847453-47-8
12352005
Aldehyde Oxidase (AO) ; Drug Derivative
Metabolic Enzyme/Protease; Others
Infection
O=C1SC2=CN=C(N)N=C2N1[C@H]3[C@@H]([C@@H]([C@@H](CO)O3)OC(C)=O)OC(C)=O
C14H16N4O7S
384.36
[1]Xiang AX, et al. Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine. Nucleosides Nucleotides Nucleic Acids. 2007;26 (6-7) :635-40.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19844/
Reference compound1
Phase 1
Beschrijving
ANA975, 5-amino-3-β -D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one derivative, is an oral prodrug of the TLR-7 agonist Isatoribine. ANA975 is converted to I
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