ANAPC5 Antilichaam - middengebied: Biotine (ARP43211 P050-Biotine)

Anaphase promoting complex subunit 5

APC5

51433

Q9UJX4-2

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of Human ANAPC5

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.

ANAPC2; UBE2S; UBC; ANAPC4; HECW2; LATS2; PHF8; SOX2; PTEN; CDC27; BACH1; TRIM33; ANAPC7; ANAPC15; CDH1; CDC20; PAXIP1; MDC1; TP53BP1; NOTCH1; ANAPC1; ANAPC13; CDC16; CDC23; FBXO5; USP37; CUL4A; SH3KBP1; E2F1; SMARCAD1; MAPK6; Gm9174; Anapc5; Mad2l1; Anap

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

24kDa

Wet Ice

219

ANAPC5

ANAPC5

Rabbit

Anaphase-promoting complex subunit 5

HSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGHYTSPP