Androgenreceptor (fosfo Tyr363) Antilichaam

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease) . Mutations in this gene are also associated with complete androgen insensitivity (CAIS) . Two alternatively spliced variants encoding distinct isoforms have been described.

367

P10275

NP_000035.2

Human, Mouse

Androgen Receptor (phospho Tyr363) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 363 (D-Y-Y (p) -N-F) derived from Human Androgen Receptor.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

85 kDa

IgG

The antibody detects endogenous levels of Androgen Receptor only when phosphorylated at tyrosine 363.

Western Blot: 1:500~1:1000

AR

Androgen receptor

Homo sapiens

Lubahn D.B., Mol. Endocrinol. 2:1265-1275 (1988) .

Chang C., Proc. Natl. Acad. Sci. U.S.A. 85:7211-7215 (1988) .

Tilley W.D., Proc. Natl. Acad. Sci. U.S.A. 86:327-331 (1989) .

ANDR, Androgen receptor, Dihydrotestosterone receptor, NR3C4

WB

21322252

Liquid