Angiopoëtine 1 Antilichaam / ANGPT1

This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Mutations in this gene are associated with hereditary angioedema.

Immunohistochemistry (FFPE) : 1-2 µg/mL

Q15389

Human

A portion of amino acids 1-200 from human AGPAT1 protein was used as the immunogen for the Angiopoietin 1 antibody.

ANGPT1/3651

IHC-P

Protein G affinity

Purified

This Angiopoietin 1 antibody is available for research use only.

Aliquot the Angiopoietin 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Optimal dilution of the Angiopoietin 1 antibody should be determined by the researcher.

Secreted, Intracellular

IHC staining of FFPE human hepatocellular carcinoma tissue with Angiopoietin 1 antibody (clone ANGPT1/3651) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.