ANGPTL3 Antilichaam

The angiopoietin-related protein 3 (ANGPTL3) is a member of a family of secreted proteins that function in angiogenesis (1) . ANGPTL3 is processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis (2,3) . Recent experiments have shown that a deficiency of ANGPTL3 is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids, suggesting that ANGPTL3 may also play a role in modulating glucose metabolism (4) .

27329

Q9Y5C1

NP_055310

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis, Obesity

ANGPTL3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1301 - Human Heart Tissue Lysate

1 mg/mL

ANGPTL3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ANGPTL3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

ANGPTL3 antibody is human, mouse and rat reactive. ANGPTL3 antibody is predicted not to cross-react with other ANGPTL family proteins.

ANGPTL3

Angiopoietin-like 3

Homo sapiens

Conklin D, Gilbertson D, Taft DW, et al. Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics 1999; 62:477-82.

Koishi R, Ando Y, Ono M, et al. Angptl3 regulates lipid metabolism in mice. Nat. Genet. 2002; 30:151-7.

Camenisch G, Pisabarro MT, Sherman D, et al. ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.J. Biol. Chem. 2002; 277:17281-90.

Robciuc MR, Maranghi M, Lahikainen A, et al. Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids. Arterioscler. Thromb. Vasc. Biol. 2013; 33:1706-13.

ANGPTL3 Antibody: ANL3, ANG-5, FHBL2, ANGPT5, UNQ153/PRO179, Angiopoietin-related protein 3, Angiopoietin-5

ELISA, WB, IHC-P, IF

7656888

Liquid