Anti-3'-5' RNA helicase YTHDC2 YTHDC2 Antilichaam

Boster Bio Anti-3'-5' RNA helicase YTHDC2 YTHDC2 Antibody catalog # A09692. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

3'-5' RNA helicase YTHDC2 ;3.6.4.13

YTHDC2

Q9H6S0

Human, Mouse, Rat

Recombinant fusion protein of human YTHDC2 (NP_073739.3) .

Expressed in testis (PubMed:29087293) . Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (PubMed:29087293) .

WB

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

1 mg/mL

Liquid

3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321) . Specifically recognizes and binds N6-methyladenosine (m6A) - containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321) . Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity) . Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321) . Required for both spermatogenesis and oogenesis (By similarity) .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A09692

160248 MW

WB: 1:500-1:2000

3'-5' RNA helicase YTHDC2

Cytoplasm

3'-5' RNA helicase YTHDC2

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2