Anti-5 Lipoxygenase/ALOX5 Antibody Picoband® fluoro488 Vervoeging

Arachidonate 5-lipoxygenase, also known as 5-LOX or 5-LO, is an enzyme that in humans is encoded by the ALOX5 gene. ALOX5 is a member of the lipoxygenase family of enzymes. It is mapped to 10q11.21. ALOX5 plays a dual role in the synthesis of leukotrienes from arachidonic acid. The position of ALOX5 within the nucleus of resting cells determines the capacity to generate LTB4 upon subsequent activation. It is involved in lung vascular tone regulation and in the development of chronic pulmonary hypertension in hypoxic rodent models. ALOX5 also transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.

Arachidonate 5-lipoxygenase;5-LO;5-lipoxygenase;1.13.11.34; ALOX5; LOG5

ALOX5

240

P09917

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human ALOX5 recombinant protein (Position: A120-R483) . Human ALOX5 shares 94% amino acid (aa) sequence identity with both mouse and rat ALOX5.

Flow Cytometry

Lipid and Lipoprotein Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. .

1. Luo, M., Jones, S. M., Peters-Golden, M., Brock, T. G. Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B (4) synthetic capacity. Proc. Nat. Acad. Sci. 100: 12165-12170, 2003. 2. Chu, J., Pratico, D. 5-lipoxygenase as an endogenous modulator of amyloid-beta formation in vivo. Ann. Neurol. 69: 34-46, 2011.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

77983 MW

No cross reactivity with other proteins.

6

Arachidonate 5-lipoxygenase

Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.

Belongs to the lipoxygenase family.

Arachidonate 5-lipoxygenase

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.