Anti-53BP1 TP53BP1 Konijn Monoklonale Antilichaam

Boster Bio Anti-53BP1 TP53BP1 Rabbit Monoclonal Antibody catalog # M00397. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Tumor suppressor p53-binding protein 1;53BP1; p53-binding protein 1; p53BP1; TP53BP1

TP53BP1

7158

Q12888

Human, Mouse, Rat

A synthesized peptide derived from human 53BP1

Clone: ABAI-20

Released primarily from activated T lymphocytes.

WB, IHC, ICC, IF, Flow Cytometry

Cancer, DNA/RNA, DNA Damage & Repair, DNA Damage Response, Epigenetics and Nuclear Signaling, Oncoproteins/Suppressors, p53 Pathway, Tumor Suppressors

Affinity-chromatography

0.5mg/ml

Liquid

Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00397

213574 MW

450 kDa

Tumor suppressor p53-binding protein 1

Nucleus. Chromosome, centromere, kinetochore. Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed.

T-cell surface glycoprotein CD4

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.