Anti-A2aR Gezuiverd

Adenosine A2a receptor (A2aR) is expressed mainly in the brain, heart and on cells of the immune system. Its ligand, extracellular adenonosine, is generated in local tissues under hypoxic, ischemic or inflammatory conditions, and can lead to increased A2aR expression. This receptor has neuromodulatory functions, affects cardiac rhythm, cerebral and renal blood flow, sleep, neurodegenerative disorders, and is involved also in pain regulation. It is a novel therapeutic target for depression. In human and murine monocytes and macrophages A2aR modulates the production of inflammatory cytokines.

Rabbit, Dog, Mouse, Rat, Human, Sheep, Guinea pig

Recombinant full length human A2aR

A2aR

7F6-G5-A2

WB (reported), ICC (reported), FC-IC (QC tested), IHC-F (reported), IHC-P (reported)

1 mg/mL

Purified

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

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Store at 2-8°C. Do not freeze.

The mouse monoclonal antibody 7F6-G5-A2 recognizes the epitope SQPLPGER within the third intracellular loop of A2aR, a 43 kDa transmembrane protein of the G protein-coupled receptor family.

Flow cytometry: Recommended dilution: 1-5 μg/ml. Intracellular staining.

Mouse IgG2a