Anti-ABCG4 Antibody Picoband® fluoro488 Vervoeging

ABCG4 (ATP-Binding Cassette, Subfamily G, Member 4), is a protein that in humans is encoded by the ABCG4 gene. The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. This protein is a member of the White subfamily and is expressed predominantly in liver tissue. By genomic sequence analysis, Engel et al. (2001) mapped the ABCG4 gene to chromosome 11q23.3. Engel et al. (2001) demonstrated 5-fold induction of ABCG4 following treatment of normal monocyte-derived macrophages with the LXR and RXR agonists 9-cis retinoic acid and 22R hydroxycholesterol. Removal of cholesterol from macrophages by cyclodextrin decreased ABCG4 message levels.

ATP-binding cassette sub-family G member 4; ABCG4; WHITE2

ABCG4

64137

Q9H172

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human ABCG4, different from the related mouse and rat sequences by one amino acid.

Highly expressed in brain tissues with the exception of the spinal cord. .

Flow Cytometry

Cancer, Cardiovascular, Cell Type Marker, Cholesterol Metabolism, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Neuron Marker, Neuroscience, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

May be involved in macrophage lipid homeostasis.

1. Annilo, T., Tammur, J., Hutchinson, A., Rzhetsky, A., Dean, M., Allikmets, R. Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4. Cytogenet. Cell Genet. 94: 196-201, 2001. 2. Engel, T., Lorkowski, S., Lueken, A., Rust, S., Schluter, B., Berger, G., Cullen, P., Assmann, G. The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages. Biochem. Biophys. Res. Commun. 288: 483-488, 2001. 3. Yoshikawa, M., Yabuuchi, H., Kuroiwa, A., Ikegami, Y., Sai, Y., Tamai, I., Tsuji, A., Matsuda, Y., Yoshida, H., Ishikawa, T. Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4. Gene 293: 67-75, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

71896 MW

No cross reactivity with other proteins.

6

ATP-binding cassette sub-family G member 4

Membrane ; Multi-pass membrane protein .

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

ATP-binding cassette sub-family G member 4

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.