Anti-ACAT2 Antibody Picoband® 31.0550 Vervoeging

Acetyl-CoA acetyltransferase, cytosolic, also known as cytosolic acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT2 (acetyl-Coenzyme A acetyltransferase 2) gene. The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2A; CAMKA; KIAA0968

ACAT2

39

Q9BWD1

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human ACAT2 recombinant protein (Position: Q31-E397) .

High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.

Flow Cytometry

Calcium Signaling, Calmodulin Pathway, Cardiovascular, Hypertrophy, Neuroscience, Neurotransmission, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity.

1. Ashworth, A. Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes. Genomics 18: 195-198, 1993. 2. de Groot, C. J., Luit-de Haan, G., Hulstaert, C. E., Hoomes, F. A. A patient with severe neurologic symptoms and acetoacetyl-CoA thiolase deficiency. Pediat. Res. 11: 1112-1116, 1977. 3. Laudet, V., Begue, A., Henry-Duthoit, C., Joubel, A., Martin, P., Stehelin, D., Saule, S. Genomic organization of the human thyroid hormone alpha (c-erbA-1) gene. Nucleic Acids Res. 19: 1105-1112, 1991.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Calcium/calmodulin dependent protein kinase II alpha

Synapse. Postsynaptic density. Dendritic spine. Dendrite.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.