Anti-Acetyl-Histone H2B (K126) HIST1H2BA Antilichaam

Boster Bio Anti-Acetyl-Histone H2B (K126) HIST1H2BA Antibody catalog # A09942. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Histone H2B type 1-A; Histone H2B, testis; TSH2B.1; Testis-specific histone H2B; HIST1H2BA; TSH2B

HIST1H2BA

Q96A08

Human, Mouse, Rat

The antiserum was produced against synthesized Acetyl-peptide derived from human H2B around the Acetylation site of Lys126. AA range:78-127

Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level) . Also found in some fat cells. .

WB, ELISA

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.

1 mg/mL

Liquid

Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity) . Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A09942

14167 MW

Histone H2B type 1-A

Nucleus. Chromosome.

IgG

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.