Anti-ACP2 Antibody Picoband® 0,00647 Vervoeging

Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene. The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism.

ACP2

53

P11117

Human, Mouse, Rat

E.coli-derived human ACP2 recombinant protein (Position: R31-H88) . Human ACP2 shares 98.3% and 96.6% amino acid (aa) sequence identity with mouse and rat ACP2, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Beckman, G., Beckman, L., Tarnvik, A. A rare subunit variant shared by five acid phosphatase isozymes from human leukocytes and placentae. Hum. Hered. 20: 81-85, 1970. 2. Bruns, G. A. P., Gerald, P. S. Human acid phosphatase in somatic cell hybrids. Science 184: 480-482, 1974. 3. Harris, H., Hopkinson, D. A., Robson, E. B. The incidence of rare alleles determining electrophoretic variants: data on 43 enzyme loci in man. Ann. Hum. Genet. 37: 237-253, 1974.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

48,18 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.