Anti-ACSL5 Antibody Picoband® 31.0550 Vervoeging

Long-chain-fatty-acidoA ligase 5 is an enzyme that in humans is encoded by the ACSL5 gene. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.

ACSL5

51703

Q9ULC5

Human, Mouse, Rat

E.coli-derived human ACSL5 recombinant protein (Position: Y108-D683) . Human ACSL5 shares 80.7% and 80.2% amino acid (aa) sequence identity with mouse and rat ACSL5, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Al-Thihli, K., Afting, C., Al-Hashmi, N., Mohammed, M., Sliwinski, S., Al Shibli, N., Al-Said, K., Al-Kasbi, G., Al-Kharusi, K., Merle, U., Fullekrug, J., Al-Maawali, A. Deficiency of acyl-CoA synthetase 5 is associated with a severe and treatable failure to thrive of neonatal onset. Clin. Genet. 99: 376-383, 2021. 2. O'Brien, M. J., Beijerink, N. J., Sansom, M., Thornton, S. W., Chew, T., Wade, C. M. A large deletion on CFA28 omitting ACSL5 gene is associated with intestinal lipid malabsorption in the Australian Kelpie dog breed. Sci. Rep. 10: 18223, 2020. 3. Oikawa, E., Iijima, H., Suzuki, T., Sasano, H., Sato, H., Kamataki, A., Nagura, H., Kang, M. J., Fujino, T., Suzuki, H., Yamamoto, T. T. A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes. J. Biochem. 124: 679-685, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

76 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.