Anti-ACTH/POMC Antilichaam fluoro488 Vervoeging

Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus) . Its principal effects are increased production and release of corticosteroids. ACTH stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells, especially in the zona fasciculata of the adrenal glands. This gene can influence steroid hormone secretion by both rapid short-term mechanisms that take place within minutes and slower long-term actions. Besides, ACTH also enhances transcription of mitochondrial genes that encode for subunits of mitochondrial oxidative phosphorylation systems.

Pro-opiomelanocortin; POMC; Corticotropin-lipotropin; NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin; POMC

POMC

5443

P01189

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human ACTH, different from the related mouse and rat sequences by two amino acids.

ACTH and MSH are produced by the pituitary gland.

Flow Cytometry

Endocrine System, Energy Metabolism, Growth Factors/Hormones, Hormone Biosynthesis, Metabolic Signaling Pathway, Metabolism, Neurology Process, Neuropeptides, Neuroscience, Neurotransmitter, Pathways and Processes, Signal Transduction, Tumor Biomarkers

Immunogen affinity purified.

Liquid

ACTH stimulates the adrenal glands to release cortisol.

1. Dibner, Charna; Schibler, Ueli; Albrecht, Urs (2010) . The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks. Annual Review of Physiology72: 517–549. 2. Hanukoglu I, Feuchtwanger R, Hanukoglu A (November 1990) . Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells. J. Biol. Chem. 265 (33) : 20602–8. 3. Raikhinstein M, Zohar M, Hanukoglu I (February 1994) . cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor. Biochim. Biophys. Acta 1220 (3) : 329–32.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

29424 MW

No cross reactivity with other proteins.

6

Pro-opiomelanocortin

Secreted.

Belongs to the POMC family.

Pro-opiomelanocortin

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.