Anti-ADAM19 Antibody Picoband® fluoro488 Vervoeging

ADAM19 (A Disintegrin and Metalloproteinase Domain 19), also known as MLTNB, is a human gene. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Hirohata et al. (1998) used radiation hybrids to map ADAM19 to mouse chromosome 11 and to human chromosome 5q32-q33.

Disintegrin and metalloproteinase domain-containing protein 19; ADAM 19;3.4.24.-; Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker; MADDAM; ADAM19; MLTNB; FKSG34

ADAM19

8728

Q9H013

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human ADAM19, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Expressed in many normal organ tissues and several cancer cell lines.

Flow Cytometry

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Immunogen affinity purified.

Liquid

Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity) . .

1. Hirohata, S., Seldin, M. F., Apte, S. S. Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11. Genomics 54: 178-179, 1998. 2. Inoue, D., Reid, M., Lum, L., Kratzschmar, J., Weskamp, G., Myung, Y. M., Baron, R., Blobel, C. P. Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells. J. Biol. Chem. 273: 4180-4187, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

104997 MW

No cross reactivity with other proteins.

6

Disintegrin and metalloproteinase domain-containing protein 19

Membrane; Single-pass type I membrane protein.

Contains 1 disintegrin domain.

Disintegrin and metalloproteinase domain-containing protein 19

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.