Anti-ADAM2 Antibody Picoband® 31.0550 Vervoeging

ADAM2 (A Disintegrin and Metalloproteinase Domain 2), also known as FTNB or PH30, is an enzyme that in humans is encoded by the ADAM2 gene. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Burkin et al. (1997) used fluorescence in situ hybridization to map the FTNB gene to 8p11.2.

Disintegrin and metalloproteinase domain-containing protein 2; ADAM 2; Cancer/testis antigen 15; CT15; Fertilin subunit beta; PH-30; PH30; PH30-beta; ADAM2; FTNB

ADAM2

2515

Q99965

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human ADAM2.

Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.

Flow Cytometry

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Immunogen affinity purified.

Liquid

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

1. Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (Aug 1996) . Molecular cloning of the human fertilin beta subunit. Biochem Biophys Res Commun 224 (2) : 318–26. 2. Burkin, H. R., Burkin, D. J., Davey, P. M., Griffin, D. K., Affara, N. A. Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB) . Genomics 40: 190-192, 1997.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

82457 MW

No cross reactivity with other proteins.

6

Disintegrin and metalloproteinase domain-containing protein 2

Membrane; Single-pass type I membrane protein.

Contains 1 disintegrin domain.

Disintegrin and metalloproteinase domain-containing protein 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.