Anti-ADAMTS9 Antibody Picoband® 31.0647 Vervoeging

A disintegrin and metalloproteinase with thrombospondin motifs 9 is an enzyme that in humans is encoded by the ADAMTS9 gene. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.

Solute carrier family 12 member 5; Electroneutral potassium-chloride cotransporter 2; K-Cl cotransporter 2; hKCC2; Neuronal K-Cl cotransporter; SLC12A5; KCC2; KIAA1176

ADAMTS9

56999

Q9P2N4

Human, Rat

No cross-reactivity with other proteins.

E.coli-derived human ADAMTS9 recombinant protein (Position: F288-H1853) .

Brain specific. Detected in neuronal cells.

Flow Cytometry

Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels

Immunogen affinity purified.

Liquid

Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl- homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl- levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.

1. Clark, M. E., Kelner, G. S., Turbeville, L. A., Boyer, A., Arden, K. C., Maki, R. A. ADAMTS9, a novel member of the ADAM-TS/metallospondin gene family. Genomics 67: 343-350, 2000. 2. Lo, P. H. Y., Leung, A. C. C., Kwok, C. Y. C., Cheung, W. S. Y., Ko, J. M. Y., Yang, L. C., Law, S., Wang, L. D., Li, J., Stanbridge, E. J., Srivastava, G., Tang, J. C. O., Tsao, S. W., Lung, M. L. Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9. Oncogene 26: 148-157, 2007. 3. Nagase, T., Kikuno, R., Ishikawa, K., Hirosawa, M., Ohara, O. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7: 65-73, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Solute carrier family 12 member 5

Membrane. Multi-pass membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.