Anti-ADAR1/ADAR Antibody Picoband® fluoro647 Vervoeging

Double-stranded RNA-specific adenosine deaminase is an enzyme that in humans is encoded by the ADAR gene. This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.

Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; T-cell antigen 4-1BB; CD137; Tnfrsf9; Cd137; Ila; Ly63

ADAR

103

P55265

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human ADAR1/ADAR recombinant protein (Position: M1-E1152) .

Expressed on the surface of activated T-cells.

Flow Cytometry

Apoptosis, Associated Proteins, Cancer, Cell Biology, Cell Death, Cell Type Markers, Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Lymphoid, Receptors, Stem Cells, T Lymphocytic Lineage, TNF Superfamily, Tumor Immunology

Immunogen affinity purified.

Liquid

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

1. Agranat, L., Raitskin, O., Sperling, J., Sperling, R. The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus. Proc. Nat. Acad. Sci. 105: 5028-5033, 2008. 2. Bass, B. L., Weintraub, H. An unwinding activity that covalently modifies its double-stranded RNA substrate. Cell 55: 1089-1098, 1988. 3. Chao, S.-C., Huang, C.-Y., Yang, M.-H. A novel nonsense mutation of the DSRAD gene in a Taiwanese family with dyschromatosis symmetrica hereditaria. Europ. J. Derm. 16: 449-540, 2006.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

TNF receptor superfamily member 9

Membrane; Single-pass type I membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.