Anti-Ager Antibody Picoband® 31.0550 Vervoeging

Enables S100 protein binding activity; advanced glycation end-product binding activity; and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of long-term synaptic potentiation; and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of advanced glycation end-product receptor activity; and positive regulation of macromolecule metabolic process. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Human ortholog (s) of this gene implicated in several diseases, including autoimmune disease (multiple) ; cardiovascular system disease (multiple) ; cystic fibrosis; kidney failure (multiple) ; and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor) .

Tumor necrosis factor-inducible gene 6 protein; Hyaluronate-binding protein; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6; TNF alpha-induced protein 6; TNFAIP6; TSG6

Ager

11596

Q62151

Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived mouse Ager recombinant protein (Position: Q24-E320) .

Found in the synovial fluid of patients with rheumatoid arthritis. .

Flow Cytometry

Cancer, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Immunology, Innate Immunity, Invasion/Microenvironment, Macrophage/Inflammation, Signal Transduction

Immunogen affinity purified.

Liquid

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.

1. Bierhaus, A., Haslbeck, K.-M., Humpert, P. M., Liliensiek, B., Dehmer, T., Morcos, M., Sayed, A. A. R., Andrassy, M., Schiekofer, S., Schneider, J. G., Schulz, J. B., Heuss, D., and 12 others. Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily. J. Clin. Invest. 114: 1741-1751, 2004. 2. Chavakis, T., Bierhaus, A., Al-Fakhri, N., Schneider, D., Witte, S., Linn, T., Nagashima, M., Morser, J., Arnold, B., Preissner, K. T., Nawroth, P. P. The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment. J. Exp. Med. 198: 1507-1515, 2003. 3. Deane, R., Yan, S. D., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., Zhu, H., Ghiso, J., and 11 others. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nature Med. 9: 907-913, 2003.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

31203 MW

6

Tumor necrosis factor-inducible gene 6 protein

Late endosome membrane. Peripheral membrane protein. Prevacuolar compartment membrane.

Tumor necrosis factor-inducible gene 6 protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.