Anti-AGO1 Antibody Picoband® fluoro488 Vervoeging

This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon.

Protein argonaute-1; Argonaute1; hAgo1; Argonaute RISC catalytic component 1; Eukaryotic translation initiation factor 2C 1; eIF-2C 1; eIF2C 1; Putative RNA-binding protein Q99; AGO1; EIF2C1

AGO1

26523

Q9UL18

Human

No cross-reactivity with other proteins

E.coli-derived human AGO1 recombinant protein (Position: K131-R171) .

Detected in blood plasma (at protein level) .

Flow Cytometry

Cell Biology, Cell Cycle, Cell Division, Cytokinesis, DNA/RNA, Epigenetics and Nuclear Signaling, Nuclear Receptors, Nuclear Signaling Pathways, RNA Processing, Translation

Immunogen affinity purified.

Liquid

Required for RNA-mediated gene silencing (RNAi) . Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs) . .

1. Guo, S.; Kemphues, K.J. (1995) . par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. 81 (4) : 611–620. 2. Hannon, GJ (2002) . RNA interference. Nature.418 (6894) : 244–51. 3. Meins F, Jr; Si-Ammour, A; Blevins, T (2005) . RNA silencing systems and their relevance to plant development.. Annual Review of Cell and Developmental Biology. 21 (1) : 297–318.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

97214 MW

6

Protein argonaute-1

Cytoplasm, P-body .

Protein argonaute-1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.