Anti-AKAP 95/AKAP8 Antilichaam Picoband® fluoro594 Vervoeging

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene. This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9.

Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1; SLC6A1; GABATR, GABT1, GAT1

AKAP8

10270

O43823

Human

No cross-reactivity with other proteins.

E.coli-derived human AKAP 95/AKAP8 recombinant protein (Position: T380-F546) .

Expressed in many tissues, highest levels in skeletal muscle.

Flow Cytometry

Neuroscience, Neurotransmitter, Transporters

Immunogen affinity purified.

Liquid

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

1. Eide, T., Coghlan, V., Orstavik, S., Holsve, C., Solberg, R., Skalhegg, B. S., Lamb, N. J. C., Langeberg, L., Fernandez, A., Scott, J. D., Jahnsen, T., Tasken, K. Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. Exp. Cell Res. 238: 305-316, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

67074 MW

6

Sodium- and chloride-dependent GABA transporter 1

Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity) . .

Long-chain-fatty-acid--CoA ligase 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.