Anti-Akirine-2 Akirin2 Antilichaam

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α and IL-1β signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Boster Bio Anti-Akirin-2 Akirin2 Antibody (Catalog # A08948) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

FBI1, C6orf166, dJ486L4.2, Akirin-2

AKIRIN2

Q53H80

Human, Mouse

Akirin2 antibody was raised against a 15 amino acid synthetic peptide near the center of the human Akirin2. The immunogen is located within amino acids 50 - 100 of Akirin2.

Widely expressed with the highest expression in peripheral blood leukocytes.

ELISA, WB

Innate Immunity

Akirin2 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity) . .

Akirin2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A08948

22496 MW

Akirin 2

Nucleus

Rat, Bovine

Akirin 2

IgG

Akirin2 Antibody is supplied in PBS containing 0.02% sodium azide.