Anti-AKR1C3 Antibody Picoband® fluoro647 Vervoeging

Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.

Thy-1 membrane glycoprotein; CDw90; Thy-1 antigen; CD90; THY1

AKR1C3

8644

P42330

Human

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the C-terminus of human AKR1C3.

Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297) . Detected in the islet of Langerhans (PubMed:21483673) .

Flow Cytometry

Neuroscience, Stem Cells, Synapse Marker, T Cells, T Lymphocytic Lineage

Immunogen affinity purified.

Liquid

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

1. Khanna, M., Qin, K.-N., Klisak, I., Belkin, S., Sparkes, R. S., Cheng, K.-C. Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization. Genomics 25: 588-590, 1995. 2. Khanna, M., Qin, K.-N., Wang, R. W., Cheng, K.-C. Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3-alpha-hydroxysteroid dehydrogenases. J. Biol. Chem. 270: 20162-20168, 1995. 3. Mills, K. I., Gilkes, A. F., Sweeney, M., Choudhry, M. A., Woodgate, L. J., Bunce, C. M., Brown, G., Burnett, A. K. Identification of a retinoic acid responsive aldoketoreductase expressed in HL60 leukaemic cells. FEBS Lett. 440: 158-162, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

18080 MW

6

Thy-1 cell surface antigen

Cell membrane; Lipid-anchor, GPI-anchor.

Thy-1 membrane glycoprotein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.