Anti-ALAS2/ASB Antibody Picoband® fluoro647 Vervoeging

Delta-aminolevulinate synthase 2 also known as ALAS2 is a protein that in humans is encoded by the ALAS2 gene. The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.

Endothelin-converting enzyme 1; ECE-1;3.4.24.71; ECE1

ALAS2

212

P22557

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human ALAS2/ASB recombinant protein (Position: M1-D190) .

All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney. .

Flow Cytometry

Cancer, Cancer Metabolism, Cardiovascular, Growth Factors/Hormones, Metabolism, Metabolism Processes, Pathways and Processes, Response To Hypoxia, Signal Transduction, Vasculature

Immunogen affinity purified.

Liquid

Converts big endothelin-1 to endothelin-1. .

1. Aoki, Y., Urata, G., Takaku, F. Delta-aminolevulinic acid synthetase activity in erythroblasts of patients with primary sideroblastic anemia. Acta Haemat. Jpn. 36: 74-77, 1973. 2. Astner, I., Schulze, J. O., van den Heuvel, J., Jahn, D., Schubert, W.-D., Heinz, D. W. Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans. EMBO J. 24: 3166-3177, 2005. 3. Astrin, K. H., Bishop, D. F. Assignment of human erythroid delta-aminolevulinate synthase (ALAS2) to the X chromosome. (Abstract) Cytogenet. Cell Genet. 51: 953-954, 1989.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

87164 MW

6

Endothelin-converting enzyme 1

Cell membrane; Single-pass type II membrane protein.

Endothelin-converting enzyme 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.