Anti-ALDH1A1 Antibody Picoband® (monoclonal, 4C3) 310647 Vervoeging

Aldehyde dehydrogenase 1 family, member A1, also known as ALDH1A1 or retinaldehyde dehydrogenase 1 (RALDH1), is an enzyme that in humans is encoded by the ALDH1A1 gene. It is mapped to 9q21.13. The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet.

Keratin, type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18; KRT18; CYK18; PIG46

ALDH1A1

216

P00352

Human

No cross-reactivity with other proteins.

E.coli-derived human ALDH1A1 recombinant protein (Position: T6-Q342) .

Clone: 4C3

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

Flow Cytometry

DNA/RNA, DNA Damage & Repair, DNA Damage Response, DNA Synthesis, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6) -mediated barrier protection.

1. Eckey, R., Agarwal, D. P., Saha, N., Goedde, H. W. Detection and partial characterization of a variant form of cytosolic aldehyde dehydrogenase isozyme. Hum. Genet. 72: 95-97, 1986. 2. Hempel, J., von Bahr-Lindstrom, H., Jornvall, H. Aldehyde dehydrogenase from human liver: primary structure of the cytoplasmic isoenzyme. Europ. J. Biochem. 141: 21-35, 1984.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Keratin 18

Nucleolus. Perinuclear region.

Keratin, type I cytoskeletal 18

Mouse IgG2a

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.