Anti-Alfa SNAP/NAPA Antibody Picoband® fluoro647 Vervoeging

N-ethylmaleimide-sensitive factor Attachment Protein Alpha, also known as SNAP-α, is a SNAP protein that is involved in the intra-cellular trafficking and fusing of vesicles to target membranes in cells. This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene.

Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1; SLC6A1; GABATR, GABT1, GAT1

NAPA

8775

P54920

Human

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the N-terminus of human Alpha SNAP/NAPA, which shares 95.7% amino acid (aa) sequence identity with mouse and rat NAPA.

Expressed in many tissues, highest levels in skeletal muscle.

Flow Cytometry

Neuroscience, Neurotransmitter, Transporters

Immunogen affinity purified.

Liquid

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

1. Andreeva, A. V., Kutuzov, M. A., Vaiskunaite, R., Profirovic, J., Meigs, T. E., Predescu, S., Malik, A. B., Voyno-Yasenetskaya, T. G-alpha-12 interaction with alpha-SNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. J. Biol. Chem. 280: 30376-30383, 2005. 2. Bronson, R. T., Lane, P. W. Hydrocephalus with hop gait (hyh) : a new mutation on chromosome 7 in the mouse. Dev. Brain Res. 54: 131-136, 1990. 3. Chae, T. H., Allen, K. M., Davisson, M. T., Sweet, H. O., Walsh, C. A. Mapping of the mouse hyh gene to a YAC/BAC contig on proximal chromosome 7. Mammalian Genome 13: 239-244, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

67074 MW

6

Sodium- and chloride-dependent GABA transporter 1

Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity) . .

Long-chain-fatty-acid--CoA ligase 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.