Anti-alfa-synnucleine-antilichaam

Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD) . Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.

Our Anti-Alpha-synuclein sheep polyclonal primary antibody detects human and rat Alpha-synuclein , and is affinity-purified. It is validated for use in IHC-Frozen, IHC-Paraffin-embedded.

Our Anti-Alpha-synuclein sheep polyclonal primary antibody detects human and rat Alpha-synuclein, and is affinity-purified. It is validated for use in IHC-Frozen, IHC-Paraffin-embedded.

Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP

P37840

Human and Rat

A synthetic peptide (PQEGILEDMPVDPC) of human alpha synuclein protein (aa: 108-120) conjugated to diphtheria toxoid has been used as the immunogen.

Alpha-synuclein

Unconjugated

IHC-Frozen, IHC-Paraffin-embedded

Affinity-purified

For research use only.

25°C (ambient)

Spin vial briefly before opening. Reconstitute in 50 μL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Affinity purified and dialysed against PBS. Contains 0.02% sodium azide.

1 μg/mL

Immunihistochemical analysis of human and rat brain indicates a high level of specificity for this antiserum. Specificity was also confirmed by Western blot. This antiserum is known to react with human and rat alpha synuclein.

Sheep

Lyophilized

IgG

Human