Anti-ALG3 Antibody Picoband® fluoro594 Vervoeging

Dolichyl-P-Man:Man (5) GlcNAc (2) -PP-dolichyl mannosyltransferase is an enzyme that, in humans, is encoded by the ALG3 gene. This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene.

Growth arrest and DNA damage-inducible protein GADD45 gamma; Cytokine-responsive protein CR6; DNA damage-inducible transcript 2 protein; DDIT-2; GADD45G; CR6; DDIT2

ALG3

10195

Q92685

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human ALG3 recombinant protein (Position: I61-H438) .

Flow Cytometry

Apoptosis, Associated Proteins, Cell Biology, Cell Cycle, Cell Division, DNA/RNA, DNA Damage & Repair, DNA Damage Response, Epigenetics and Nuclear Signaling, Intracellular

Immunogen affinity purified.

Liquid

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

1. Denecke, J., Kranz, C., Kemming, D., Koch, H.-G., Marquardt, T. An activated 5-prime cryptic splice site in the human ALG3 gene generates a premature termination codon insensitive to nonsense-mediated mRNA decay in a new case of congenital disorder of glycosylation type Id (CDG-Id) . Hum. Mutat. 23: 477-486, 2004. 2. Denecke, J., Kranz, C., von Kleist-Retzow, J. C., Bosse, K., Herkenrath, P., Debus, O., Harms, E., Marquardt, T. Congenital disorder of glycosylation type Id: clinical phenotype, molecular analysis, prenatal diagnosis, and glycosylation of fetal proteins. Pediat. Res. 58: 248-253, 2005. 3. Korner, C., Knauer, R., Stephani, U., Marquardt, T., Lehle, L., von Figura, K. Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man (5) GlcNAc (2) -PP-dolichyl mannosyltransferase. EMBO J. 18: 6816-6822, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Growth arrest and DNA damage inducible gamma

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.