Anti-Alkaline Fosfatase/ALPL Antibody Picoband® fluoro550 Vervoeging

Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific) . The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. Liver/bone/kidney alkaline phosphatase, also known as tissue-nonspecific alkaline phosphatase, acts physiologically as a lipid-anchored phosphoethanolamine (PEA) and pyridoxal-5-prime-phosphate (PLP) ectophosphatase Mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked ly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects.

Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNSALP;3.1.3.1; Alkaline phosphatase liver/bone/kidney isozyme; Alpl

ALPL

P08289

P08289

Mouse, Rat

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the N-terminus of rat Alkaline Phosphatase, different from the related mouse sequence by one amino acid.

Widely expressed, with highest expression in brain. .

Flow Cytometry

Cancer, Cell Biology, Cell Cycle, Kinases/Phosphatases, Tags & Cell Markers, Tumor Biomarkers

Immunogen affinity purified.

Liquid

This isozyme may play a role in skeletal mineralization.

1. Weiss MJ, Henthorn PS, Lafferty MA, Slaughter C, Raducha M, Harris H (Oct 1986) . Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase. Proc Natl Acad Sci U S A 83 (19) : 7182–6. 2. Swallow DM, Povey S, Parkar M, Andrews PW, Harris H, Pym B, Goodfellow P (May 1988) . Mapping of the gene coding for the human liver/bone/kidney isozyme of alkaline phosphatase to chromosome 1. Ann Hum Genet 50 (Pt 3) : 229–35. 3. Entrez Gene: ALPL alkaline phosphatase, liver/bone/kidney 4. Fedde, K. N., Whyte, M. P. Alkaline phosphatase (tissue-nonspecific isoenzyme) is a phosphoethanolamine and pyridoxal-5-prime-phosphate ectophosphatase: normal and hypophosphatasia fibroblast study. Am. J. Hum. Genet. 47: 767-775, 1990.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

57659 MW

No cross reactivity with other proteins.

6

Alkaline phosphatase, tissue-nonspecific isozyme

Cell membrane; Lipid-anchor, GPI-anchor.

Contains 12 fibronectin type-I domains.

Alkaline phosphatase, tissue-nonspecific isozyme

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.