Anti-ALOX5AP Antibody Picoband® 310647 Vervoeging

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

ALOX5AP; FLAP; Arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein

ALOX5AP

241

P20292

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human ALOX5AP, identical to the related mouse and rat sequences.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Dixon, R. A. F., Diehl, R. E., Opas, E., Rands, E., Vickers, P. J., Evans, J. F., Gillard, J. W., Miller, D. K. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343: 282-284, 1990. 2. Ferguson, A. D., McKeever, B. M., Xu, S., Wisniewski, D., Miller, D. K., Yamin, T.-T., Spencer, R. H., Chu, L., Ujjainwalla, F., Cunningham, B. R., Evans, J. F., Becker, J. W. Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein. Science 317: 510-512, 2007. 3. Kennedy, B. P., Diehl, R. E., Boie, Y., Adam, M., Dixon, R. A. F. Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP) . J. Biol. Chem. 266: 8511-8516, 1991.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

18 kDa

6

Arachidonate 5-lipoxygenase activating protein

Arachidonate 5-lipoxygenase-activating protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.